Annotation Overview for fig|64091.1.peg.311 in Halobacterium sp. NRC-1:
NAD-specific glutamate dehydrogenase (EC 1.4.1.2); NADP-specific glutamate dehydrogenase (EC 1.4.1.4)

current assignment	We are uncertain of the precise function of this feature. It is probably one of the following: NAD-specific glutamate dehydrogenase (EC 1.4.1.2) EC Number 1.4.1.2 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) EC Number 1.4.1.4 NAD-specific glutamate dehydrogenase (EC 1.4.1.2); NADP-specific glutamate dehydrogenase (EC 1.4.1.4)
taxonomy id	64091	contig	64091.1:NC_001869 (191,347bp)64091.1:NC_002607 (2,014,240bp)64091.1:NC_002608 (365,426bp)
internal links	genome browser | feature evidence | sequence	ACH Annotation Clearinghouse (ACH) The Annotation Clearinghouse offers a mapping of genes which are identical in sequence except for the start region (due to differences in start calling). [?]	show essentially identical genes
PubMed links	15780999
annotation history		run tool	Psi-BlastTMpredTMHMMGram negative PSORTGram negative SignalPGram positive PSORTGram positive SignalPLipoPInterProScanRadarPPSearchGram negative CELLOGram positive CELLOProDomPDB
FigFam	FIG110317
data base cross references (dbxref)	NCBI: 56671099 UniProt: Q9HSM4 RefSeq: NP_279299.1 NCBI: 12230035 UniProt: DHE42_HALSA NCBI: 10579809 CMR: NTL01HS0135 NCBI: 15789475

Annotation History (history of similar genes)

Date	Annotator	Annotation
8/6/2004	MattC	Set FIG function to NADP-specific glutamate dehydrogenase (EC 1.4.1.4)
6/27/2007	AndreiO	Set FIG function to NAD-specific glutamate dehydrogenase (EC 1.4.1.2); NADP-specific glutamate dehydrogenase (EC 1.4.1.4)
6/27/2007	AndreiO	It is a temporary annotation. Apparently it is a challenge to sort these two cofactor preferences in teh family Clearly: 1. In E. coli - it is 1.4.1.4 2. In B.subtilis - it is 1.4.1.2 3. In mammals - bifunctional. More analysis needed to set boundaries. (The "large" GDH as in Streptomyces is a separate story - tehy are NAD preferring)
11/1/2008	SvetaG	Set FIG function to NADP-specific glutamate dehydrogenase (EC 1.4.1.4)
11/5/2008	SvetaG	Set FIG function to NAD-specific glutamate dehydrogenase (EC 1.4.1.2); NADP-specific glutamate dehydrogenase (EC 1.4.1.4)

We are uncertain of the precise function of the encoded protein. It is probably "NAD-specific glutamate dehydrogenase (EC 1.4.1.2)" or "NADP-specific glutamate dehydrogenase (EC 1.4.1.4)". The protein occurs in 3 subsystems: "Arginine and Ornithine Degradation", "Glutamate dehydrogenases", and "Proline, 4-hydroxyproline uptake and utilization". The function of this gene is asserted in 15780999. The function of genes having the same functional roles have been described in Drosophila melanogaster (10992165, 6810872), Homo sapiens (10636977, 11214910, 11254391, 11297618, 11903050, 12054821, 12653548, 3368458, 3377777, 3399399, 3426581, 3585334, 429360, 8207021, 8314555, 8486350, 9571255), Sulfolobus solfataricus (1730244), Arabidopsis thaliana (11743114), Rattus norvegicus (1684101, 2704624, 2704625, 8094669, 9275181) and Mus musculus (1711373). These are homologous proteins which implement the same function.

The chromosomal region of the focus gene (top) is compared with four similar organisms. The graphic is centered on the focus gene, which is red and numbered 1. Sets of genes with similar sequence are grouped with the same number and color. Genes whose relative position is conserved in at least four other species are functionally coupled and share gray background boxes. The size of the region and the number of genomes may be reset. Click on any arrow in the display to refocus the comparison on that gene. The focus gene always points to the right, even if it is located on the minus strand.